Induction of macrophage-mediated hepatocytotoxicity by culture supernatant from LPS-activated Kupffer cells.
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LPS-activated complement, not LPS per se, triggers the early release of PGE2 by Kupffer cells.
The intravenous injection of LPS rapidly evokes fever. We have hypothesized that its onset is mediated by prostaglandin (PG)E(2) quickly released by Kupffer cells (Kc). LPS, however, does not stimulate PGE(2) production by Kc as rapidly as it induces fever; but complement (C) activated by LPS could be the exciting agent. To test this hypothesis, we injected LPS (2 or 8 microg/kg) or cobra venom...
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Thakur, Varsha, Michele T. Pritchard, Megan R. McMullen, and Laura E. Nagy. Adiponectin normalizes LPS-stimulated TNFproduction by rat Kupffer cells after chronic ethanol feeding. Am J Physiol Gastrointest Liver Physiol 290: G998–G1007, 2006. First published January 12, 2006; doi:10.1152/ajpgi.00553.2005.—Chronic ethanol feeding sensitizes Kupffer cells to activation by lipopolysaccharide (LPS)...
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ژورنال
عنوان ژورنال: Kanzo
سال: 1985
ISSN: 0451-4203,1881-3593
DOI: 10.2957/kanzo.26.877